Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1)

Classical nonhomologous DNA end-joining (C-NHEJ), which is a major DNA double-strand break (DSB) repair pathway in mammalian cells, plays a dominant role in joining DSBs during Ig heavy chain (IgH) class switch recombination (CSR) in activated B lymphocytes. However, in B cells deficient for one or...

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Autori principali: Boboila, Cristian, Oksenych, Valentyn, Gostissa, Monica, Wang, Jing H., Zha, Shan, Zhang, Yu, Chai, Hua, Lee, Cheng-Sheng, Jankovic, Mila, Saez, Liz-Marie Albertorio, Nussenzweig, Michel C., McKinnon, Peter J., Alt, Frederick W., Schwer, Bjoern
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289296/
https://ncbi.nlm.nih.gov/pubmed/22308491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121470109
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