Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis

Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid mediator that promotes breast cancer progression by diverse mechanisms that remain somewhat unclear. Here we report pharmacological evidence of a critical role for sphingosine kinase 1 (SphK1) in producing S1P and mediating tumor-induced...

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Autori principali: Nagahashi, Masayuki, Ramachandran, Subramaniam, Kim, Eugene Y., Allegood, Jeremy C., Rashid, Omar M., Yamada, Akimitsu, Zhao, Renping, Milstien, Sheldon, Zhou, Huiping, Spiegel, Sarah, Takabe, Kazuaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289261/
https://ncbi.nlm.nih.gov/pubmed/22298596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-2167
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