Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription

In MKN1 gastric cancer cells, lysophosphatidic acid (LPA) upregulates expression of sphingosine kinase 1 (SphK1) and its downregulation or inhibition suppresses LPA-mediated proliferation. Although LPA activates numerous signaling pathways downstream of its receptors, including ERK1/2, p38, JNK, and...

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Hauptverfasser: Ramachandran, Subramaniam, Shida, Dai, Nagahashi, Masayuki, Fang, Xianjun, Milstien, Sheldon, Takabe, Kazuaki, Spiegel, Sarah
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947956/
https://ncbi.nlm.nih.gov/pubmed/20804754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.08.035
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