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Chemical inhibition of fatty acid synthase: molecular docking analysis and biochemical validation in ocular cancer cells
Fatty acid biosynthesis is an attractive target for anti-cancer therapeutics. The ocular cancer, retinoblastoma cells were treated with fatty acid synthase (FASN) enzyme inhibitors: cerulenin, triclosan and orlistat. The IC(50) and dose-dependent sensitivity of cancer cells to FASN inhibitors decrea...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Springer-Verlag
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3289161/ https://ncbi.nlm.nih.gov/pubmed/23181152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12177-011-9065-7 |
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