Chemical inhibition of fatty acid synthase: molecular docking analysis and biochemical validation in ocular cancer cells

Fatty acid biosynthesis is an attractive target for anti-cancer therapeutics. The ocular cancer, retinoblastoma cells were treated with fatty acid synthase (FASN) enzyme inhibitors: cerulenin, triclosan and orlistat. The IC(50) and dose-dependent sensitivity of cancer cells to FASN inhibitors decrea...

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Detaylı Bibliyografya
Asıl Yazarlar: Deepa, P. R., Vandhana, S., Muthukumaran, S., Umashankar, V., Jayanthi, U., Krishnakumar, S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer-Verlag 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289161/
https://ncbi.nlm.nih.gov/pubmed/23181152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12177-011-9065-7
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