Inhibition of Hepatitis C Virus NS5B Polymerase by S-Trityl-L-Cysteine Derivatives

Structure-based studies led to the identification of a constrained derivative of S-trityl-L-cysteine (STLC) scaffold as a candidate inhibitor of hepatitis C virus (HCV) NS5B polymerase. A panel of STLC derivatives were synthesized and investigated for their activity against HCV NS5B. Three STLC deri...

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Detalhes bibliográficos
Main Authors: Nichols, Daniel B., Fournet, Guy, Gurukumar, K. R., Basu, Amartya, Lee, Jin-Ching, Sakamoto, Naoya, Kozielski, Frank, Musmuca, Ira, Joseph, Benoît, Ragno, Rino, Kaushik-Basu, Neerja
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288800/
https://ncbi.nlm.nih.gov/pubmed/22280819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2012.01.010
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