A NEW LC-MS/MS METHOD FOR THE QUANTIFICATION OF ENDOGENOUS AND VINYL CHLORIDE INDUCED 7-(2-OXOETHYL)GUANINE IN SPRAGUE DAWLEY RATS

Vinyl chloride (VC) is an industrial chemical that is known to be carcinogenic to animals and humans. VC primarily induces hepatic angiosarcomas following high exposures (≥50 ppm). VC is also found in Superfund sites at ppb concentrations as a result of microbial metabolism of trichloroethylene and...

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Detalhes bibliográficos
Main Authors: Mutlu, Esra, Jeong, Yo-Chan, Collins, Leonard B., Ham, Amy-Joan L., Upton, Patricia B., Hatch, Gary, Winsett, Darrell, Evansky, Paul, Swenberg, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288741/
https://ncbi.nlm.nih.gov/pubmed/22211352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200447w
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