DEVELOPMENT AND APPLICATION OF AN LC-MS/MS METHOD FOR THE DETECTION OF THE VINYL CHLORIDE-INDUCED DNA ADDUCT N(2),3-ETHENOGUANINE IN TISSUES OF ADULT AND WEANLING RATS FOLLOWING EXPOSURE TO [(13)C(2)]-VC

In the 1970s exposure to vinyl chloride (VC) was shown to cause liver angiosarcoma in VC workers. We have developed a new LC-MS/MS method for analyzing the promutagenic DNA adduct N(2),3-ethenoguanine (εG) and have applied this to DNA from tissues of both adult and weanling rats exposed to 1100 ppm...

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Detalhes bibliográficos
Main Authors: Mutlu, Esra, Collins, Leonard B., Stout, Matthew D., Upton, Patricia B., Daye, Laura R., Winsett, Darrell, Hatch, Gary, Evansky, Paul, Swenberg, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104734/
https://ncbi.nlm.nih.gov/pubmed/20799743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx1001767
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