Oncolytic Herpes simplex virus expressing yeast cytosine deaminase: relationship between viral replication, transgene expression, prodrug bioactivation

Yeast cytosine deaminase (yCD) is a well-characterized prodrug/enzyme system that converts 5-fluorocytosine (5-FC) to 5-fluorouracil (5-FU), and has been combined with oncolytic viruses. However, in vivo studies of the interactions between 5-FC bioactivation and viral replication have not been previ...

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Detalhes bibliográficos
Main Authors: Yamada, Suguru, Kuroda, Toshihiko, Fuchs, Bryan C., He, Xiaoying, Supko, Jeffrey G., Schmitt, Anthony, McGinn, Christopher M., Lanuti, Michael, Tanabe, Kenneth K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288710/
https://ncbi.nlm.nih.gov/pubmed/22076044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2011.70
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