Comparison of intravenous versus intraperitoneal administration of oncolytic Herpes simplex virus 1 (HSV-1) for peritoneal carcinomatosis in mice

hrR3 is an oncolytic Herpes simplex virus 1 (HSV-1) mutant that replicates preferentially in tumors compared to normal tissues. Portal venous administration of hrR3 in mice bearing diffuse colorectal carcinoma liver metastases significantly reduces tumor burden and prolongs animal survival. In the c...

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Main Authors: Kulu, Yakup, Dorfman, Jon D., Kuruppu, Darshini, Fuchs, Bryan C., Goodwin, Jonathan M., Fujii, Tsutomu, Kuroda, Toshihiko, Lanuti, Michael, Tanabe, Kenneth K.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2657185/
https://ncbi.nlm.nih.gov/pubmed/18989355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2008.83
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