Role for the guanine nucleotide exchange factor P-Rex1 in platelet secretion and aggregation

OBJECTIVE: Recent studies have shown a role for Rac1 in regulating platelet functions, but how Rac1 is activated in platelets remains unclear. PIP3-dependent Rac exchanger 1 (P-Rex1) was originally identified in neutrophils that regulates phagocyte functions. We sought to examine whether P-Rex1 play...

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Hlavní autoři: Qian, Feng, Le Breton, Guy C., Chen, Jia, Deng, Jing, Christman, John W., Wu, Dianqing, Ye, Richard D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288658/
https://ncbi.nlm.nih.gov/pubmed/22207728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.243675
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