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Intracellular trafficking of P-glycoprotein
Overexpression of P-glycoprotein (P-gp) is a major cause of multidrug resistance in cancer. P-gp is mainly localized in the plasma membrane and can efflux structurally and chemically unrelated substrates, including anticancer drugs. P-gp is also localized in intracellular compartments, such as ER, G...
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| Główni autorzy: | , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2011
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3288648/ https://ncbi.nlm.nih.gov/pubmed/22212176 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2011.12.009 |
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