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Where is it and How Does it Get There – Intracellular Localization and Traffic of P-glycoprotein
P-glycoprotein (P-gp), an ATP-binding cassette, is able to transport structurally and chemically unrelated substrates. Over-expression of P-gp in cancer cells significantly decreases the intercellular amount of anticancer drugs, and results in multidrug resistance in cancer cells, a major obstacle i...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3874554/ https://ncbi.nlm.nih.gov/pubmed/24416721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00321 |
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