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Where is it and How Does it Get There – Intracellular Localization and Traffic of P-glycoprotein

P-glycoprotein (P-gp), an ATP-binding cassette, is able to transport structurally and chemically unrelated substrates. Over-expression of P-gp in cancer cells significantly decreases the intercellular amount of anticancer drugs, and results in multidrug resistance in cancer cells, a major obstacle i...

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Bibliographic Details
Main Author: Fu, Dong
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874554/
https://ncbi.nlm.nih.gov/pubmed/24416721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00321
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