IRF5 activation in monocytes of SLE patients is triggered by circulating autoantigens independent of type I IFN

OBJECTIVE: Genetic variants of interferon regulatory factor 5 (IRF5) are associated with susceptibility to systemic lupus erythematosus (SLE). IRF5 regulates the expression of proinflammatory cytokines and type I interferons (IFN) believed to be involved in SLE pathogenesis. The aim of this study wa...

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Détails bibliographiques
Auteurs principaux: Stone, Rivka C., Feng, Di, Deng, Jing, Singh, Sukhwinder, Yang, Lisong, Fitzgerald-Bocarsly, Patricia, Eloranta, Maija-Leena, Rönnblom, Lars, Barnes, Betsy J.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288585/
https://ncbi.nlm.nih.gov/pubmed/21968701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.33395
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