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Fibrillization Propensity for Short Designed Hexapeptides Predicted by Computer Simulation
Assembly of normally soluble proteins into ordered aggregates, known as amyloid fibrils, is a cause or associated symptom of numerous human disorders, including Alzheimer’s and the prion diseases. Here we test the ability of discontinuous molecular dynamics (DMD) simulations based on PRIME20, a new...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3288580/ https://ncbi.nlm.nih.gov/pubmed/22227390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.12.038 |
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