Inhibition of Hematopoietic Protein Tyrosine Phosphatase Augments and Prolongs ERK1/2 and p38 Activation

The hematopoietic protein tyrosine phosphatase (HePTP) is implicated in the development of blood cancers through its ability to negatively regulate the mitogen-activated protein kinases (MAPKs) ERK1/2 and p38. Small-molecule modulators of HePTP activity may become valuable in treating hematopoietic...

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Detalhes bibliográficos
Main Authors: Sergienko, Eduard, Xu, Jian, Liu, Wallace H., Dahl, Russell, Critton, David A., Su, Ying, Brown, Brock T., Chan, Xochella, Yang, Li, Bobkova, Ekaterina V., Vasile, Stefan, Yuan, Hongbin, Rascon, Justin, Colayco, Sharon, Sidique, Shyama, Cosford, Nicholas D.P., Chung, Thomas D.Y., Mustelin, Tomas, Page, Rebecca, Lombroso, Paul J., Tautz, Lutz
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288537/
https://ncbi.nlm.nih.gov/pubmed/22070201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb2004274
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