Quantification of Irinotecan, SN38, and SN38G in human and porcine plasma by ultra high-performance liquid chromatography-tandem mass spectrometry and its application to hepatic chemoembolization

An analytical method was developed and validated for the quantitative determination of irinotecan, its active metabolite SN38, and glucuronidated SN38 (SN38-G) in both porcine and human plasma. Calibration curves were linear within the concentration range of 0.5–100 ng/mL for SN38 and SN38-G, and 5–...

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Bibliografiske detaljer
Main Authors: Chen, Xiaohong, Peer, Cody J., Alfaro, Raul, Tian, Tian, Spencer, Shawn D., Figg, William D.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288457/
https://ncbi.nlm.nih.gov/pubmed/22305081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2012.01.008
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