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Quantitative Determination of Irinotecan and the Metabolite SN-38 by Nanoflow Liquid Chromatography-Tandem Mass Spectrometry in Different Regions of Multicellular Tumor Spheroids

A new and simple method was developed to evaluate the distribution of therapeutics in three-dimensional multicellular tumor spheroids (MCTS) by combining serial trypsinization and nanoflow liquid chromatography-tandem mass spectrometry (nLC-MS/MS). This methodology was validated with quantitative me...

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Detaylı Bibliyografya
Yayımlandı:J Am Soc Mass Spectrom
Asıl Yazarlar: Liu, Xin, Hummon, Amanda B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361235/
https://ncbi.nlm.nih.gov/pubmed/25604392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-014-1071-0
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