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Occludin is required for apoptosis when claudin–claudin interactions are disrupted

Disruption of tight junctions is often seen during pathogen infection, inflammation, and tumor progression. Mislocalization of the tight junction proteins occludin and claudin in mammary epithelial monolayers leads to apoptosis through the extrinsic pathway. To further investigate the mechanism of t...

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Autori principali: Beeman, N, Webb, P G, Baumgartner, H K
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288343/
https://ncbi.nlm.nih.gov/pubmed/22361748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.14
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