Monocytic CCR2+ Myeloid Derived Suppressor Cells Promote Immune Escape By Limiting Activated CD8 T Cell Infiltration Into The Tumor Microenvironment

Myeloid derived suppressor cells (MDSC) are a heterogeneous population of cells that accumulate during tumor formation, facilitate immune escape and enable tumor progression. MDSC are important contributors to the development of an immunosuppressive tumor microenvironment that blocks the action of c...

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Detalhes bibliográficos
Main Authors: Lesokhin, Alexander M., Hohl, Tobias M., Kitano, Shigehisa, Cortez, Czrina, Hirschhorn-Cymerman, Daniel, Avogadri, Francesca, Rizzuto, Gabrielle A., Lazarus, John J., Pamer, Eric G., Houghton, Alan N., Merghoub, Taha, Wolchok, Jedd D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288305/
https://ncbi.nlm.nih.gov/pubmed/22174368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-1792
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