Defibrotide interferes with several steps of the coagulation-inflammation cycle and exhibits therapeutic potential to treat severe malaria

OBJECTIVES: The coagulation-inflammation cycle has been implicated as a critical component in malaria pathogenesis. Defibrotide (DF), a mixture of DNA aptamers, displays anticoagulant, anti-inflammatory, and endothelial cell (EC)-protective activities and has been successfully used to treat comatose...

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Autors principals: Francischetti, Ivo M. B., Oliveira, Carlo J., Ostera, Graciela R., Yager, Stephanie B., Debierre-Grockiego, Françoise, Carregaro, Vanessa, Jaramillo-Gutierrez, Giovanna, Hume, Jen C., Jiang, Lubin, Moretz, Samuel E., Lin, Christina K., Ribeiro, José M.C., Long, Carole A., Vickers, Brandy K., Schwarz, Ralph T., Seydel, Karl B., Iacobelli, Massimo, Ackerman, Hans C., Srinivasan, Prakash, Gomes, Regis B., Wang, Xunde, Monteiro, Robson Q., Kotsyfakis, Michail, Sá-Nunes, Anderson, Waisberg, Michael
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288196/
https://ncbi.nlm.nih.gov/pubmed/22116094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.240291
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