Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure

Hepatic veno-occlusive disease (VOD), also called sinusoidal obstruction syndrome (SOS), is a potentially life-threatening complication of hematopoietic stem cell transplantation (HSCT). Untreated hepatic VOD/SOS with multi-organ failure (MOF) is associated with >80% mortality. Defibrotide has sh...

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Publicat a:Blood
Autors principals: Richardson, Paul G., Riches, Marcie L., Kernan, Nancy A., Brochstein, Joel A., Mineishi, Shin, Termuhlen, Amanda M., Arai, Sally, Grupp, Stephan A., Guinan, Eva C., Martin, Paul L., Steinbach, Gideon, Krishnan, Amrita, Nemecek, Eneida R., Giralt, Sergio, Rodriguez, Tulio, Duerst, Reggie, Doyle, John, Antin, Joseph H., Smith, Angela, Lehmann, Leslie, Champlin, Richard, Gillio, Alfred, Bajwa, Rajinder, D’Agostino, Ralph B., Massaro, Joseph, Warren, Diane, Miloslavsky, Maja, Hume, Robin L., Iacobelli, Massimo, Nejadnik, Bijan, Hannah, Alison L., Soiffer, Robert J.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2016
Matèries:
Clinical Trials and Observations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817309/
https://ncbi.nlm.nih.gov/pubmed/26825712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-10-676924
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