Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure

Hepatic veno-occlusive disease (VOD), also called sinusoidal obstruction syndrome (SOS), is a potentially life-threatening complication of hematopoietic stem cell transplantation (HSCT). Untreated hepatic VOD/SOS with multi-organ failure (MOF) is associated with >80% mortality. Defibrotide has sh...

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Enregistré dans:
Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Richardson, Paul G., Riches, Marcie L., Kernan, Nancy A., Brochstein, Joel A., Mineishi, Shin, Termuhlen, Amanda M., Arai, Sally, Grupp, Stephan A., Guinan, Eva C., Martin, Paul L., Steinbach, Gideon, Krishnan, Amrita, Nemecek, Eneida R., Giralt, Sergio, Rodriguez, Tulio, Duerst, Reggie, Doyle, John, Antin, Joseph H., Smith, Angela, Lehmann, Leslie, Champlin, Richard, Gillio, Alfred, Bajwa, Rajinder, D’Agostino, Ralph B., Massaro, Joseph, Warren, Diane, Miloslavsky, Maja, Hume, Robin L., Iacobelli, Massimo, Nejadnik, Bijan, Hannah, Alison L., Soiffer, Robert J.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2016
Sujets:
Clinical Trials and Observations
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817309/
https://ncbi.nlm.nih.gov/pubmed/26825712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-10-676924
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