Defibrotide interferes with several steps of the coagulation-inflammation cycle and exhibits therapeutic potential to treat severe malaria

OBJECTIVES: The coagulation-inflammation cycle has been implicated as a critical component in malaria pathogenesis. Defibrotide (DF), a mixture of DNA aptamers, displays anticoagulant, anti-inflammatory, and endothelial cell (EC)-protective activities and has been successfully used to treat comatose...

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Main Authors: Francischetti, Ivo M. B., Oliveira, Carlo J., Ostera, Graciela R., Yager, Stephanie B., Debierre-Grockiego, Françoise, Carregaro, Vanessa, Jaramillo-Gutierrez, Giovanna, Hume, Jen C., Jiang, Lubin, Moretz, Samuel E., Lin, Christina K., Ribeiro, José M.C., Long, Carole A., Vickers, Brandy K., Schwarz, Ralph T., Seydel, Karl B., Iacobelli, Massimo, Ackerman, Hans C., Srinivasan, Prakash, Gomes, Regis B., Wang, Xunde, Monteiro, Robson Q., Kotsyfakis, Michail, Sá-Nunes, Anderson, Waisberg, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288196/
https://ncbi.nlm.nih.gov/pubmed/22116094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.240291
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