Structural Characterisation of Tpx from Yersinia pseudotuberculosis Reveals Insights into the Binding of Salicylidene Acylhydrazide Compounds

Thiol peroxidase, Tpx, has been shown to be a target protein of the salicylidene acylhydrazide class of antivirulence compounds. In this study we present the crystal structures of Tpx from Y. pseudotuberculosis (ypTpx) in the oxidised and reduced states, together with the structure of the C61S mutan...

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Hauptverfasser: Gabrielsen, Mads, Beckham, Katherine S. H., Feher, Victoria A., Zetterström, Caroline E., Wang, Dai, Müller, Sylke, Elofsson, Mikael, Amaro, Rommie E., Byron, Olwyn, Roe, Andrew J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288085/
https://ncbi.nlm.nih.gov/pubmed/22384182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032217
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