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Aptamers as a Sensitive Tool to Detect Subtle Modifications in Therapeutic Proteins
Therapeutic proteins are derived from complex expression/production systems, which can result in minor conformational changes due to preferential codon usage in different organisms, post-translational modifications, etc. Subtle conformational differences are often undetectable by bioanalytical metho...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3288073/ https://ncbi.nlm.nih.gov/pubmed/22384109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031948 |
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