Preventing Phosphorylation of Sterol Regulatory Element-Binding Protein 1a by MAP-Kinases Protects Mice from Fatty Liver and Visceral Obesity

The transcription factor sterol regulatory element binding protein (SREBP)-1a plays a pivotal role in lipid metabolism. Using the SREBP-1a expressing human hepatoma cell line HepG2 we have shown previously that human SREBP-1a is phosphorylated at serine 117 by ERK-mitogen-activated protein kinases (...

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Main Authors: Kotzka, Jorg, Knebel, Birgit, Haas, Jutta, Kremer, Lorena, Jacob, Sylvia, Hartwig, Sonja, Nitzgen, Ulrike, Muller–Wieland, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287979/
https://ncbi.nlm.nih.gov/pubmed/22384276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032609
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