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Liver-Specific Expression of Transcriptionally Active SREBP-1c Is Associated with Fatty Liver and Increased Visceral Fat Mass

The pathogenesis of fatty liver is not understood in detail, but lipid overflow as well as de novo lipogenesis (DNL) seem to be the key points of hepatocyte accumulation of lipids. One key transcription factor in DNL is sterol regulatory element-binding protein (SREBP)-1c. We generated mice with liv...

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Bibliografiske detaljer
Main Authors: Knebel, Birgit, Haas, Jutta, Hartwig, Sonja, Jacob, Sylvia, Köllmer, Cornelia, Nitzgen, Ulrike, Muller–Wieland, Dirk, Kotzka, Jorg
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283692/
https://ncbi.nlm.nih.gov/pubmed/22363740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031812
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