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Methods for adjusting population structure and familial relatedness in association test for collective effect of multiple rare variants on quantitative traits

Because of the low frequency of rare genetic variants in observed data, the statistical power of detecting their associations with target traits is usually low. The collapsing test of collective effect of multiple rare variants is an important and useful strategy to increase the power; in addition,...

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Bibliografski detalji
Glavni autori: Zhang, Qunyuan, Chung, Doyoung, Kraja, Aldi, Borecki, Ingrid I, Province, Michael A
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287871/
https://ncbi.nlm.nih.gov/pubmed/22373066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1753-6561-5-S9-S35
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