pre-miRNA profiles obtained through application of locked nucleic acids and deep sequencing reveals complex 5′/3′ arm variation including concomitant cleavage and polyuridylation patterns

Recent research hints at an underappreciated complexity in pre-miRNA processing and regulation. Global profiling of pre-miRNA and its potential to increase understanding of the pre-miRNA landscape is impeded by overlap with highly expressed classes of other non coding (nc) RNA. Here, we present a da...

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Hauptverfasser: Burroughs, A. Maxwell, Kawano, Mitsuoki, Ando, Yoshinari, Daub, Carsten O., Hayashizaki, Yoshihide
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2012
Schlagworte:
Computational Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287202/
https://ncbi.nlm.nih.gov/pubmed/22058130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr903
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