A comprehensive survey of 3′ animal miRNA modification events and a possible role for 3′ adenylation in modulating miRNA targeting effectiveness

Animal microRNA sequences are subject to 3′ nucleotide addition. Through detailed analysis of deep-sequenced short RNA data sets, we show adenylation and uridylation of miRNA is globally present and conserved across Drosophila and vertebrates. To better understand 3′ adenylation function, we deep-se...

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Autors principals: Burroughs, A. Maxwell, Ando, Yoshinari, de Hoon, Michiel J.L., Tomaru, Yasuhiro, Nishibu, Takahiro, Ukekawa, Ryo, Funakoshi, Taku, Kurokawa, Tsutomu, Suzuki, Harukazu, Hayashizaki, Yoshihide, Daub, Carsten O.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2010
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945189/
https://ncbi.nlm.nih.gov/pubmed/20719920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.106054.110
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