PAPD5-mediated 3′ adenylation and subsequent degradation of miR-21 is disrupted in proliferative disease

Next-generation sequencing experiments have shown that microRNAs (miRNAs) are expressed in many different isoforms (isomiRs), whose biological relevance is often unclear. We found that mature miR-21, the most widely researched miRNA because of its importance in human disease, is produced in two prev...

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Detalhes bibliográficos
Main Authors: Boele, Joost, Persson, Helena, Shin, Jay W., Ishizu, Yuri, Newie, Inga S., Søkilde, Rolf, Hawkins, Shannon M., Coarfa, Cristian, Ikeda, Kazuhiro, Takayama, Ken-ichi, Horie-Inoue, Kuniko, Ando, Yoshinari, Burroughs, A. Maxwell, Sasaki, Chihiro, Suzuki, Chizuru, Sakai, Mizuho, Aoki, Shintaro, Ogawa, Ayumi, Hasegawa, Akira, Lizio, Marina, Kaida, Kaoru, Teusink, Bas, Carninci, Piero, Suzuki, Harukazu, Inoue, Satoshi, Gunaratne, Preethi H., Rovira, Carlos, Hayashizaki, Yoshihide, de Hoon, Michiel J. L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128123/
https://ncbi.nlm.nih.gov/pubmed/25049417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317751111
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