Ischemia-induced stimulation of cerebral microvascular endothelial cell Na-K-Cl cotransport involves p38 and JNK MAP kinases

Previous studies have provided evidence that, in the early hours of ischemic stroke, a luminal membrane blood-brain barrier (BBB) Na-K-Cl cotransporter (NKCC) participates in ischemia-induced cerebral edema formation. Inhibition of BBB NKCC activity by intravenous bumetanide significantly reduces ed...

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Detalhes bibliográficos
Main Authors: Wallace, Breanna K., Jelks, Karen A., O'Donnell, Martha E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Membrane Transporters, Ion Channels and Pumps
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287160/
https://ncbi.nlm.nih.gov/pubmed/22049209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00261.2011
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