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Characterizing low affinity epibatidine binding to α4β2 nicotinic acetylcholine receptors with ligand depletion and nonspecific binding
BACKGROUND: Along with high affinity binding of epibatidine (K(d1)≈10 pM) to α4β2 nicotinic acetylcholine receptor (nAChR), low affinity binding of epibatidine (K(d2)≈1-10 nM) to an independent binding site has been reported. Studying this low affinity binding is important because it might contribut...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3287110/ https://ncbi.nlm.nih.gov/pubmed/22112852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2046-1682-4-19 |
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