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Loss of adenomatous polyposis coli in Bergmann glia disrupts their unique architecture and leads to cell non-autonomous neurodegeneration of cerebellar Purkinje neurons
The tumor suppressor adenomatous Polyposis Coli (APC) is a multifunctional protein that inhibits the Wnt/beta-catenin signaling pathway and regulates the microtubule and actin cytoskeletons. Using conditional knockout (CKO) mice in which the APC gene is inactivated in glial fibrillary acidic protein...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3287075/ https://ncbi.nlm.nih.gov/pubmed/21381115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.21154 |
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