Loss of adenomatous polyposis coli in Bergmann glia disrupts their unique architecture and leads to cell non-autonomous neurodegeneration of cerebellar Purkinje neurons

The tumor suppressor adenomatous Polyposis Coli (APC) is a multifunctional protein that inhibits the Wnt/beta-catenin signaling pathway and regulates the microtubule and actin cytoskeletons. Using conditional knockout (CKO) mice in which the APC gene is inactivated in glial fibrillary acidic protein...

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Hauptverfasser: Wang, Xiaohong, Imura, Tetsuya, Sofroniew, Michael V., Fushiki, Shinji
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287075/
https://ncbi.nlm.nih.gov/pubmed/21381115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.21154
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