Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity

Hsp90 is an essential and highly conserved modular molecular chaperone whose N and middle domains are separated by a disordered region termed the charged linker. Although its importance has been previously disregarded, because a minimal linker length is sufficient for Hsp90 activity, the evolutionar...

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Bibliografske podrobnosti
Main Authors: Tsutsumi, Shinji, Mollapour, Mehdi, Prodromou, Chrisostomos, Lee, Chung-Tien, Panaretou, Barry, Yoshida, Soichiro, Mayer, Matthias P., Neckers, Leonard M.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287002/
https://ncbi.nlm.nih.gov/pubmed/22315411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114414109
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