Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction

Calorie restriction (CR) is a dietary intervention that extends lifespan and healthspan in a variety of organisms. CR improves mitochondrial energy production, fuel oxidation, and reactive oxygen species (ROS) scavenging in skeletal muscle and other tissues, and these processes are thought to be cri...

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Detalhes bibliográficos
Main Authors: Finley, Lydia W. S., Lee, Jaewon, Souza, Amanda, Desquiret-Dumas, Valérie, Bullock, Kevin, Rowe, Glenn C., Procaccio, Vincent, Clish, Clary B., Arany, Zoltan, Haigis, Marcia C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286952/
https://ncbi.nlm.nih.gov/pubmed/22308395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115813109
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