Enzyme functional evolution through improved catalysis of ancestrally nonpreferred substrates

In this study, we investigated the role for ancestral functional variation that may be selected upon to generate protein functional shifts using ancestral protein resurrection, statistical tests for positive selection, forward and reverse evolutionary genetics, and enzyme functional assays. Data are...

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Bibliographische Detailangaben
Hauptverfasser: Huang, Ruiqi, Hippauf, Frank, Rohrbeck, Diana, Haustein, Maria, Wenke, Katrin, Feike, Janie, Sorrelle, Noah, Piechulla, Birgit, Barkman, Todd J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286912/
https://ncbi.nlm.nih.gov/pubmed/22315396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019605109
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