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Enzyme functional evolution through improved catalysis of ancestrally nonpreferred substrates
In this study, we investigated the role for ancestral functional variation that may be selected upon to generate protein functional shifts using ancestral protein resurrection, statistical tests for positive selection, forward and reverse evolutionary genetics, and enzyme functional assays. Data are...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3286912/ https://ncbi.nlm.nih.gov/pubmed/22315396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019605109 |
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