Differential PKC-dependent and -independent PKD activation by G protein α subunits of the Gq family: selective stimulation of PKD Ser(748) autophosphorylation by Gαq

Protein kinase D (PKD) is activated within cells by stimulation of multiple G protein coupled receptors (GPCR). Earlier studies demonstrated a role for PKC to mediate rapid activation loop phosphorylation-dependent PKD activation. Subsequently, a novel PKC-independent pathway in response to Gαq-coup...

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Autori principali: Waldron, Richard T., Innamorati, Giulio, Torres-Marquez, M. Eugenia, Sinnett-Smith, James, Rozengurt, Enrique
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286641/
https://ncbi.nlm.nih.gov/pubmed/22227248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2011.12.014
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