Sequential Protein Kinase C (PKC)-dependent and PKC-independent Protein Kinase D Catalytic Activation via G(q)-coupled Receptors: DIFFERENTIAL REGULATION OF ACTIVATION LOOP SER(744) AND SER(748) PHOSPHORYLATION

Protein kinase D (PKD) is a serine/threonine protein kinase rapidly activated by G protein-coupled receptor (GPCR) agonists via a protein kinase C (PKC)-dependent pathway. Recently, PKD has been implicated in the regulation of long term cellular activities, but little is known about the mechanism(s)...

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Detalhes bibliográficos
Main Authors: Jacamo, Rodrigo, Sinnett-Smith, James, Rey, Osvaldo, Waldron, Richard T., Rozengurt, Enrique
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442337/
https://ncbi.nlm.nih.gov/pubmed/18337243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800442200
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