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Epidermal growth factor receptor downregulation by small heterodimeric binding proteins
No single engineered protein has been shown previously to robustly downregulate epidermal growth factor receptor (EGFR), a validated cancer target. A panel of fibronectin-based domains was engineered to bind with picomolar to nanomolar affinity to multiple epitopes of EGFR. Monovalent and homo- and...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3286197/ https://ncbi.nlm.nih.gov/pubmed/22160867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzr056 |
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