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Epidermal growth factor receptor downregulation by small heterodimeric binding proteins

No single engineered protein has been shown previously to robustly downregulate epidermal growth factor receptor (EGFR), a validated cancer target. A panel of fibronectin-based domains was engineered to bind with picomolar to nanomolar affinity to multiple epitopes of EGFR. Monovalent and homo- and...

詳細記述

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書誌詳細
主要な著者: Hackel, Benjamin J., Neil, Jason R., White, Forest M., Wittrup, K.Dane
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286197/
https://ncbi.nlm.nih.gov/pubmed/22160867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzr056
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