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Epidermal growth factor receptor downregulation by small heterodimeric binding proteins
No single engineered protein has been shown previously to robustly downregulate epidermal growth factor receptor (EGFR), a validated cancer target. A panel of fibronectin-based domains was engineered to bind with picomolar to nanomolar affinity to multiple epitopes of EGFR. Monovalent and homo- and...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3286197/ https://ncbi.nlm.nih.gov/pubmed/22160867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzr056 |
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