Anti-telomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer

To assess telomerase as a cancer therapeutic target and determine adaptive mechanisms to telomerase inhibition, we modeled telomerase reactivation and subsequent extinction in T-cell lymphomas arising in Atm(-/-) mice engineered with an inducible telomerase reverse transcriptase allele. Telomerase r...

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Autors principals: Hu, Jian, Hwang, Soyoon Sarah, Liesa, Marc, Gan, Boyi, Sahin, Ergun, Jaskelioff, Mariela, Ding, Zhihu, Ying, Haoqiang, Boutin, Adam T., Zhang, Hailei, Johnson, Shawn, Ivanova, Elena, Kost-Alimova, Maria, Protopopov, Alexei, Wang, Yaoqi Alan, Shirihai, Orian S., Chin, Lynda, DePinho, Ronald A.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286017/
https://ncbi.nlm.nih.gov/pubmed/22341440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.12.028
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