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Site-specific intercalation at the triplex-duplex junction induces a conformational change which is detectable by hypersensitivity to diethylpyrocarbonate.

Using site-specific intercalation directed by intermolecular triplex formation, the conformation of an intercalation site in DNA was examined by footprinting with the purine-specific (A much greater than G) reagent diethylpyrocarbonate. Site specific intercalation was achieved by covalently linking...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Principais autores: Collier, D A, Mergny, J L, Thuong, N T, Helene, C
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 1991
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC328565/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1870975/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/19.15.4219
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