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Fatty Acid Synthase Modulates Intestinal Barrier Function through Palmitoylation of Mucin 2
The intestinal mucus barrier prevents pathogen invasion and maintains host-microbiota homeostasis. We show that fatty acid synthase (FAS), an insulin-responsive enzyme essential for de novo lipogenesis, helps maintain the mucus barrier by regulating Mucin 2, the dominant mucin in the colon and a cen...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3285413/ https://ncbi.nlm.nih.gov/pubmed/22341463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2011.12.006 |
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