Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model

Inflammation is a multi-staged process whose expansive phase is thought to be driven by acutely released arachidonic acid (AA) and its metabolites. Inhibition of cyclooxygenase (COX), lipoxygenase (LOX), or soluble epoxide hydrolase (sEH) is known to be anti-inflammatory. Inhibition of sEH stabilize...

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Main Authors: Liu, Jun-Yan, Yang, Jun, Inceoglu, Bora, Qiu, Hong, Ulu, Arzu, Hwang, Sung-Hee, Chiamvimonvat, Nipavan, Hammock, Bruce D
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285377/
https://ncbi.nlm.nih.gov/pubmed/19896470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2009.10.025
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