Calpain-mediated Degradation of Myocyte Enhancer Factor 2D Contributes to Excitotoxicity by Activation of Extrasynaptic N-Methyl-d-aspartate Receptors

Synaptic and extrasynaptic NMDA receptors (NMDARs) appear to play opposite roles in neuronal survival and death. Here we report the new findings on the dysregulation of survival factor, myocyte enhancer factor 2D (MEF2D), by extrasynaptic NMDARs. Excitotoxicity led to the NMDAR-dependent degradation...

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Detalles Bibliográficos
Main Authors: Wei, Gengze, Yin, Yue, Li, Wenming, Bito, Haruhiko, She, Hua, Mao, Zixu
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285350/
https://ncbi.nlm.nih.gov/pubmed/22215669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.260109
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