Calpain-mediated Degradation of Myocyte Enhancer Factor 2D Contributes to Excitotoxicity by Activation of Extrasynaptic N-Methyl-d-aspartate Receptors

Synaptic and extrasynaptic NMDA receptors (NMDARs) appear to play opposite roles in neuronal survival and death. Here we report the new findings on the dysregulation of survival factor, myocyte enhancer factor 2D (MEF2D), by extrasynaptic NMDARs. Excitotoxicity led to the NMDAR-dependent degradation...

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Hlavní autoři: Wei, Gengze, Yin, Yue, Li, Wenming, Bito, Haruhiko, She, Hua, Mao, Zixu
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285350/
https://ncbi.nlm.nih.gov/pubmed/22215669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.260109
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