Mass Spectrometry-assisted Study Reveals That Lysine Residues 1967 and 1968 Have Opposite Contribution to Stability of Activated Factor VIII

The A2 domain rapidly dissociates from activated factor VIII (FVIIIa) resulting in a dampening of the activity of the activated factor X-generating complex. The amino acid residues that affect A2 domain dissociation are therefore critical for FVIII cofactor function. We have now employed chemical fo...

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Main Authors: Bloem, Esther, Meems, Henriet, van den Biggelaar, Maartje, van der Zwaan, Carmen, Mertens, Koen, Meijer, Alexander B.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285348/
https://ncbi.nlm.nih.gov/pubmed/22215677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.308627
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