Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria

Farnesylated prelamin A is a processing intermediate produced in the lamin A maturation pathway. Accumulation of a truncated farnesylated prelamin A form, called progerin, is a hallmark of the severe premature ageing syndrome, Hutchinson-Gilford progeria. Progerin elicits toxic effects in cells, lea...

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Bibliographische Detailangaben
Hauptverfasser: Cenni, V., Capanni, C., Columbaro, M., Ortolani, M., D'Apice, M.R., Novelli, G., Fini, M., Marmiroli, S., Scarano, E., Maraldi, N.M., Squarzoni, S., Prencipe, S., Lattanzi, G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: PAGEPress Publications 2011
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3284238/
https://ncbi.nlm.nih.gov/pubmed/22297442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4081/ejh.2011.e36
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