Rapamycin treatment of Mandibuloacral Dysplasia cells rescues localization of chromatin-associated proteins and cell cycle dynamics

Lamin A is a key component of the nuclear lamina produced through post-translational processing of its precursor known as prelamin A. LMNA mutations leading to farnesylated prelamin A accumulation are known to cause lipodystrophy, progeroid and developmental diseases, including Mandibuloacral dyspla...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Cenni, Vittoria, Capanni, Cristina, Mattioli, Elisabetta, Columbaro, Marta, Wehnert, Manfred, Ortolani, Michela, Fini, Milena, Novelli, Giuseppe, Bertacchini, Jessika, Maraldi, Nadir M., Marmiroli, Sandra, D'Apice, Maria Rosaria, Prencipe, Sabino, Squarzoni, Stefano, Lattanzi, Giovanna
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233654/
https://ncbi.nlm.nih.gov/pubmed/25324471
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